Therapyx Receives NIH Award to Pursue a Novel Therapeutic Vaccine for Genital Tract Infections

Buffalo NY- November 18, 2019.   Therapyx is pleased to announce a new SBIR Phase I award to begin development of GneXa10TM, a novel therapeutic vaccine against genital tract infection with Gonorrhea (GC). The award, in the amount of $239,162 entitled “Encapsulated anti-IL-10 for the immune therapy of gonorrhea infection” will fund proof of principle studies aimed at establishing the utility of intravaginal delivery of encapsulated anti-IL-10 antibody as a gonorrhea treatment. GneXa10TM is in addition to and separate from the company’s GneX12® product, also aimed at therapeutic GC intervention. The NIH SBIR award, from the Institute of Allergy and Infectious Disease to Dr. Yingru Liu Ph.D., will focus on pre-clinical studies based on the original findings of Dr. Michael Russell, our Chief Scientific Officer.

 “This new award will expand our efforts to capitalize on Dr. Russell’s discoveries and aims at turning an existing GC infection into a broadly effective live vaccine” said Dr. Dominick L. Auci, Vice President for Research and Development “There is currently no vaccine against Gonorrhea, and the alarming rise of drug-resistant strains threatens to make infections untreatable. This new award will allow us to continue to explore immune therapies as potential solutions that circumvent antibiotic resistance.  Over the next year, we plan to optimize GneXa10 dose and schedule in the mouse and to elucidate the basis of protective immunity. Importantly, we are gaining critical experience in encapsulation of therapeutic antibody products, which represents a new application of our EXStaM platform, hitherto focused almost exclusively on cytokines.”

Therapyx is developing a proprietary drug delivery system based on mild encapsulation of highly potent protein therapeutics into nano/microparticles that preserves bioactivity, achieves controlled tissue specific release, reduced toxicity and shelf-stability at room temperature.  Its two lead products TreXTAM® and GneX12® are aimed at IBD and mucosal infections, respectively. For more information on Therapyx, contact the Company’s website at www.therapyxinc.com

This press release contains forward-looking statements concerning the potential and prospects of the Company’s drug discovery program and its drug candidates. Any statement describing a goal, expectation, intention or belief of the Company is a forward-looking statement and should be considered an at-risk statement. Such statements are subject to certain risks and uncertainties, including the ability to complete preclinical and clinical trials successfully and within specified timelines, if at all; the ability to obtain regulatory approval; the Company’s future capital needs and ability to obtain additional funding; the ability of the Company to protect its intellectual property rights and to not infringe the intellectual property rights of others; the development of competitive products by other companies; and other risks detailed from time to time in the Company’s filings and press releases. The actual results may differ materially from those contained in this press release.

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